Fibromyalgia Pain Relief | LYRICA® (pregabalin) CV Safety Info

Relieving Fibromyalgia Pain With LYRICA

Fibromyalgia causes a distinct type of pain

Your fibromyalgia pain is different than pain you may experience from a headache or sprained ankle. That's because fibromyalgia is thought to be the result of overactive nerves that cause chronic widespread pain and tenderness.

LYRICA is approved for the management of fibromyalgia

LYRICA is approved by the US Food and Drug Administration (FDA) to be taken every day for the management of fibromyalgia. Neither over-the-counter pain relief pills nor prescription narcotics are approved by the FDA for the management of fibromyalgia. LYRICA is not an antidepressant or a narcotic. However, those who have had drug or alcohol problems may be more likely to misuse LYRICA.

LYRICA was the first treatment approved by the FDA for the management of fibromyalgia. There is no generic version of LYRICA.

LYRICA can provide significant relief from fibromyalgia pain

LYRICA can help relieve chronic widespread pain. In clinical studies, LYRICA was proven to provide significant relief from fibromyalgia pain compared with a placebo,so patients felt better and could do more.*

In clinical studies, some patients felt less fibromyalgia pain in as soon as 1 week. For others it took longer.*

LYRICA may provide you with long-lasting relief from chronic widespread pain. In a 6-month trial, most patients who felt significant fibromyalgia pain relief after 3 months of treatment with LYRICA continued to feel pain relief at the end of the trial.

Across all clinical studies, side effects were generally mild to moderate. The 2 most common side effects while taking LYRICA were dizziness and sleepiness. For some people, they went away over time. For others, they lasted throughout the course of the studies.

Other common side effects in these clinical studies included dry mouth, swelling of the hands and feet, blurred vision, weight gain, trouble concentrating, and feeling "high." Learn more about how to take LYRICA and the potential side effects of LYRICA.

*Individual results may vary.

How LYRICA is believed to work

Connected to the muscles are nerves that send messages through the body. For example,a message from the brain telling the arm to move. These messages can also be sensory messages, including pain.

Fibromyalgia is thought to be the result of overactive nerves. These nerves may be responsible for the chronic widespread pain and tenderness of fibromyalgia.

LYRICA is believed to calm overactive nerves. It is unknown exactly how LYRICA works in the body. Animal studies suggest that LYRICA reduces "extra" electrical signals sent out by overactive nerves. The implication of these studies for humans is not known.

Studies have shown that overactive nerves are a result of an imbalance of 3 naturally occurring chemicals in the body. LYRICA is believed to rebalance these chemicals.

Watch how LYRICA is believed to calm overactive nerves.

LYRICA can be taken with other medicines

LYRICA has a low potential for interaction with other medicines. Tell your doctor about all the medicines, vitamins or herbal supplements you take, especially medicines that make you sleepy or any medicines mentioned below:

Any angiotensin converting enzyme (ACE) inhibitor, used to treat many conditions such as high blood pressure: Taking this with LYRICA may increase the chance for swelling and hives

Avandia (rosiglitazone), Avandamet (contains rosiglitazone and metformin), or Actos (pioglitazone) used for diabetes: Taking these with LYRICA may increase the chance of weight gain or swelling of your hands or feet

Any narcotic pain medicine (such as oxycodone), tranquilizers or medicines for anxiety (such as lorazepam): Taking these with LYRICA may increase the chance for dizziness and sleepiness

Help your doctor understand your symptoms. Go to the next page for ideas that you can use to talk about your pain to help determine if you may have fibromyalgia.

Learn more: Talking to a Doctor

LYRICA is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles. LYRICA is also indicated to treat partial onset seizures in adults with epilepsy who take 1 or more drugs for seizures.

IMPORTANT SAFETY INFORMATION

LYRICA is not for everyone. LYRICA may cause serious, even life threatening, allergic reactions. Stop taking LYRICA and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck, or if you have any trouble breathing, or have a rash, hives or blisters.

Drugs used to treat seizures increase the risk of suicidal thoughts or behavior. LYRICA may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients, family members or caregivers should call the doctor right away if they notice suicidal thoughts or actions, thoughts of self harm, or any unusual changes in mood or behavior. These changes may include new or worsening depression, anxiety, restlessness, trouble sleeping, panic attacks, anger, irritability, agitation, aggression, dangerous impulses or violence, or extreme increases in activity or talking. If you have suicidal thoughts or actions, do not stop LYRICA without first talking to your doctor.

LYRICA may cause swelling of your hands, legs and feet, which can be serious for people with heart problems. LYRICA may cause dizziness and sleepiness. You should not drive or work with machines until you know how LYRICA affects you. Also, tell your doctor right away about muscle pain or problems along with feeling sick and feverish, or any changes in your eyesight including blurry vision, or if you have any kidney problems or get dialysis.

Some of the most common side effects of LYRICA are dizziness, blurry vision, weight gain, sleepiness, trouble concentrating, swelling of your hands and feet, dry mouth, and feeling “high.” If you have diabetes, tell your doctor about any skin sores.

You may have a higher chance for swelling and hives if you are also taking angiotensin converting enzyme (ACE) inhibitors so tell your doctor if you are taking these medications. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. Do not drink alcohol while on LYRICA. You may have a higher chance for dizziness and sleepiness if you take LYRICA with alcohol, narcotic pain medicines, or medicines for anxiety.

Before you start LYRICA, tell your doctor if you are planning to father a child, or if you are pregnant, plan to become pregnant, or are breast-feeding. If you have had a drug or alcohol problem, you may be more likely to misuse LYRICA.

In studies, a specific type of blood vessel tumor was seen in mice, but not in rats. The meaning of these findings in humans is not known.

Do not stop taking LYRICA without talking to your doctor. If you stop suddenly you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy, you may have seizures more often.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

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